[…] if you believe that the universe is not arbitrary, but is governed by definite laws, you ultimately have to combine the partial theories into a complete unified theory that will describe everything in the universe. But there is a fundamental paradox in the search for such a complete unified theory. The ideas about scientific theories outlined above assume we are rational beings who are free to observe the universe as we want and to draw logical deductions from what we see.
In such a scheme it is reasonable to suppose that we might progress ever closer toward the laws that govern our universe. Yet if there really is a complete unified theory, it would also presumably determine our actions. And so the theory itself would determine the outcome of our search for it! And why should it determine that we come to the right conclusions from the evidence? Might it not equally well determine that we draw the wrong conclusion? Or no conclusion at all? (Hawking 1988)
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Hawking, S. (1988) A Brief History of Time, London: Bantam Dell Publishing Group.